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Research By Tim Clayton

Dr Clayton is an honorary senior clinical lecturer at the University of Manchester and he has been actively involved in clinical research throughout his medical education. He is currently working closely with clinical psychologists to develop a multi-disciplinary service for young adults with severe inflammatory skin disease. This work is focussing on the severe psychological upset that may occur as a consequence of suffering from a chronic skin disease such as psoriasis, acne or eczema.

Dr Clayton’s team at Salford are currently developing a new study observing the timing of topical therapy and its effect on children with moderate or severe atopic eczema.

Dr Clayton was actively involved in a large study that helped to characterize the common filaggrin mutations occurring in children with eczema in the UK. He also was part of similar study looking at understanding the genetic basis of acne.

Dr Clayton has also been involved in major studies looking at the genetics of eczema. His adult eczema clinic is also involved in clinical trials of new biologic interventions for eczema.

If you are between the age of 18 and 45 yrs old and suffer from severe eczema then you may be eligible to enroll on one the new biologic studies for atopic eczema.

Dr Clayton has also recruited over 200 patients into a national study looking at the genetic causes of acne.

Dr Clayton has also submitted data to the PITCH study, a large international study into infantile haemangiomas. ( see peer reviewed publications below)

Dr Clayton is a member of the UK Phototherapy and Acne guidelines committees and recently published guidelines for the use of PUVA photo chemotherapy. ( see below)

Dr Clayton is currently conducting an audit on the treatment of viral warts in over 200 school children.

In addition to over 30 abstracts at scientific meetings and several book chapters.

Dr Clayton has authored/co-authored the following articles published in peer reviewed journals and accessed on pubmed.

Updated PUVA guidelines:

Ling T, Clayton TH et al. British Association of Dermatologists and British Photodermatology Group guidelines for the safe and effective use of psoralen-ultraviolet A therapy 2015. Br J Dermatol. 2016 Jan;174(1):24-55

1: Wedgeworth E, Glover M, Irvine AD, Neri I, Baselga Torres E, Clayton TH et al.Propranolol in the treatment of infantile haemangiomas: Lessons from the European Propranolol In the Treatment of Complicated Haemangiomas (PITCH) Taskforce Survey. Br J Dermatol 2015 Oct 16. doi: 10.1111/bjd.14233

2. Navarini AA, Simpson MA, Weale M, Knight J, Carlavan I, Reiniche P, Burden DA, Layton A, Clayton TH et al. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. Nat Commun 2014 Jun 13;5:4020.

3: Ellingford JM, Black GC, Clayton TH. A novel mutation in IL36RN underpins childhood pustular psoriasis. J Eur Acad Dermatol Venereol. 2015 Feb 16

4: Colbeck C, Clayton TH, Goenka A. Poison ivy dermatitis. Arch Dis Child. 2013 Dec;98(12):1022.

5: Laws PM, Porter W, Taibjee SM, Clayton TH. Topical breast milk may promote healing of ulceration in infantile haemangiomas. Clin Exp Dermatol. 2012 Dec;37(8):915-6

6: Angit C, Clayton TH. Lightning-strike granuloma. Clin Exp Dermatol. 2009 Oct;34(7):e485-6. PubMed PMID: 19747324.

7. Clayton TH and Irvine AD Klippel Trenaunay Syndrome. Journal of Lymphodema. 2008; (3) 49-51. (see article here)

8: Clayton TH, Clark SM, Britton J, Pavlov S, Radev S. A comparative study of the Children’s Dermatology Life Quality Index (CDLQI) in paediatric dermatology clinics in the UK and Bulgaria. J Eur Acad Dermatol Venereol. 2007 Nov;21(10):1436-7. PubMed PMID: 17958869.

9: Clayton TH, Barry J, Fitzgerald D, Watson R, Irvine AD. Clarithromycin suspension-associated toxic epidermal necrolysis in a 2-year-old girl. Clin ExpDermatol. 2007 Nov;32(6):755-6. Epub 2007 Aug 22. PubMed PMID: 17714526.

http://www.nature.com/ng/journal/v39/n5/full/ng2020.html

10: Sandilands A, Terron-Kwiatkowski A, Hull PR, O’Regan GM, Clayton TH, et al.Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema. Nat Genet. 2007 May;39(5):650-4. Epub 2007 Apr 8. PubMed PMID: 17417636.

11: Clayton TH, Mitra A, Holder J, Clark SM. Congenital plaque on thechest. Diagnosis: solitary giant congenital juvenile xanthogranuloma. Clin Exp Dermatol. 2007 Sep;32(5):613-4. Epub 2007 Mar 21. PubMed PMID: 17376208.

12: Usmani N, Clayton TH, Everett S, Goodfield MD. Variable response ofhidradenitis suppurativa to infliximab in four patients. Clin Exp Dermatol. 2007 Mar;32(2):204-5. PubMed PMID: 17342798.

13: Clayton TH, Clark SM, Turner D, Goulden V. The treatment of severe atopic dermatitis in childhood with narrowband ultraviolet B phototherapy. Clin Exp Dermatol. 2007 Jan;32(1):28-33. PubMed PMID: 17305905.

14: Clayton TH, Clark SM. A slowly enlarging painless nodule on the elbow. Clin Exp Dermatol. 2007 Jul;32(4):473-4. Epub 2007 Jan 30. PubMed PMID: 17263833.

15: Clayton TH, Harrison PV. Photodynamic therapy for infected leg ulcers. Br J Dermatol. 2007 Feb;156(2):384-5. PubMed PMID: 17223887.

16: Clayton TH, Walker BP, Stables GI. Treatment of chronic erythema nodosum with infliximab. Clin Exp Dermatol. 2006 Nov;31(6):823-4. PubMed PMID: 17040270.

17: Clayton TH, Ogden S, Goodfield MD. Treatment of refractory subacute cutaneous lupus erythematosus with efalizumab. J Am Acad Dermatol. 2006 May;54(5):892-5. PubMed PMID: 16635677.

18: Clayton TH, Tait J, Whitehurst C, Yates VM. Photodynamic therapy for superficial basal cell carcinoma and Bowen’s disease. Eur J Dermatol. 2006 Jan-Feb;16(1):39-41. PubMed PMID: 16436340.

19: Clayton TH, Wilkinson SM, Rawcliffe C, Pollock B, Clark SM. Allergic contact dermatitis in children: should pattern of dermatitis determine referral? A retrospective study of 500 children tested between 1995 and 2004 in one U.K. centre. Br J Dermatol. 2006 Jan;154(1):114-7. PubMed PMID: 16403103.

20: Ogden S, Clayton TH, Goodfield MJ. Recalcitrant hand pompholyx: variable response to etanercept. Clin Exp Dermatol. 2006 Jan;31(1):145-6. PubMed PMID: 16309517.

21. Clayton TH, Harrison PV, Nicholls R, Delap M. Topical tacrolimus for facial psoriasis. Br J Dermatol. 2003 Aug;149(2):419-20

22. Clayton TH, Stables GI. Reactivation of ophthalmic herpes zoster following pulsed-dye laser treatment for inflammatory acne vulgaris. Br J Dermatol. 2005 Mar;152(3):569-70

23.Cusack C, Fitzgerald D, Clayton T, Irvine AD. Successful treatment of florid cutaneous warts with intravenous cidofovir in an 11-year-old girl. Pediatr Dermatol. 2008 May-Jun;25(3):387-9.

24. Strauss RM, Bäte J, Nischal KK, Clayton T, Gooi J, Darling JC, Newton-Bishop JA. A child with laryngo-onychocutaneous syndrome partially responsive to treatment with thalidomide.Br J Dermatol. 2006 Dec;155(6):1283-6.

25. Clayton TH, Harrison PV. Successful treatment of chronic ulcerated necrobiosis lipoidica with 0.1% topical tacrolimus ointment. Br J Dermatol. 2005 Mar;152(3):581-2.

26. Clayton TH, Wilkinson SM. Contact dermatoses in healthcare workers: reduction in type I latex allergy in a UK centre. Clin Exp Dermatol. 2005 May;30(3):221-5.

Dr Tim Clayton consultant dermatologist in Manchester

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